It’s a commonly held belief that because CBD is natural, it doesn’t have side effects or any negative drug interactions, but that’s a dangerous belief to have. Take the grapefruit for example, a delicious fruit with numerous benefits including weight loss and a reduced risk of heart disease. Despite how healthy it is, eating grapefruit or drinking grapefruit juice can be very risky if you’re on certain medications.
This is because grapefruit contains compounds known as furanocoumarins, which bind to and neutralize various gut enzymes, the most important being the Cytochrome P450 enzymes. CYP450 is a group of liver enzymes that help break down and eliminate drugs from the body.
Just like the furanocoumarins in grapefruit, CBD binds to the CYP450 enzymes as well, but research suggests that it may be even more potent because it attaches in multiple parts of the gut and liver, whereas grapefruit mainly affects just the small intestine. Because of this, CBD can raise levels of certain drugs in the blood stream.
Of particular concern is the combination of CBD with anticoagulants like coumadin and Eliquis, and chemotherapy medication such as Abraxane and Cytoxan. For both of these classes of drugs, the dosage must be precise, and they’re formulated with the understanding that they will be metabolized at a certain rate. It can be detrimental if the body is getting more than what’s recommended.
What’s more, the enzymes don’t immediately go back to normal after being inhibited. It can take days, even weeks, for enzyme function to regulate after it’s been affected. It’s also worth noting that when observed in rats, CBD only inhibited CPY450 for a short period of time, but induced them after repeated use. How that plays out in the long-term remains to be seen.
There is a silver lining to this study, however, which is CBD’s affect on CYP1A1. Cannabidiol induces this enzyme, which is responsible for the degradation of carcinogenic substances. As per the publication, “CYP1A1 can be found in the intestine and CBD-induced higher activity could therefore prevent absorption of cancerogenic substances into the bloodstream and thereby help to protect DNA.”
So, this is clearly a new area of research, but it really drives home the point that CBD – being a health supplement or medication – will NOT have the same effects on everyone. It can work flawlessly for some, and for others, well, not so much. Side effects and drug interactions are possible with CBD.
Before making any changes to your health regimen, make sure to speak to a health care professional that you trust and one who knows your medical history.
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Nov. 8, Missouri residents will have the opportunity to vote on legalization of adult-use cannabis. Missouri passed a constitutional amendment for medical cannabis in 2018 and advocates are looking to build on the momentum in the state. Amendment 3, the Marijuana Legalization Initiative, is on the ballot in Missouri as an initiated constitutional amendment. If […]
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They’re not there yet, and they might not get there, but this coming November, at least three states, (and possibly six), are putting it up to voters in yet more cannabis ballot measures for recreational legalizations. Will we get up to 25 legal states by the end of elections? 2022 elections are going to be […]
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