Answer: Chronic use and high doses of up to 1500 mg per day of CBD have been repeatedly shown to be well tolerated by humans. However, for must people who use CBD, the doses they will use will be 1/4 or this amount. Bottom line – CBD is safe.
Answer: No. THC and CBD work at different areas of the brain. They do not “cross-react”. You have no cause for concern. You will not harm yourself or “overdose”.
Answer: Single dose administration of THC and CBD were evaluated in human studies. An oral dose of 600 mg of CBD did not cause any effects that were different from the placebo when given to healthy adults. In contrast, a 10-mg dose of THC produced intoxication, euphoria, and hallucinogenic activity. THC also increased psychotic symptoms, increased anxiety, and increased the heart rate. When CBD was given, none of this occurred.
Answer: CBD is a neuroprotective agent. When the cells of the body undergo hypoxic or ischemic insult such in seen in cerebral or cardiac ischemia (i.e. stroke or heart attack), CBD inhibits the uptake of adenosine. As a result, adenosine levels are increased. Increased adenosine protects against the cell damage that occurs in ischemic heart and brain injury, seizures, and inflammation.
Answer: CBD inhibits COX-2, which is the main enzyme the initiates inflammation. When the COX-2 gene is activated the hormones, which cause inflammation are released. These hormones are the cytokines (histamine and interferon) which produce the inflammation and aching pain at the site of injury, and chemokines, which recruit the white blood cells to the area of injury, and through them, mediate the rest of the inflammatory response.
Answer: CBD has an important role in the treatment of epilepsy. CBD decreases glutamate release which results in raising of the seizure threshold in the epileptic focus located in the hippocampus. CBD is an approved effective treatment for Lennox-Gastaut syndrome (LGS) in children and adults and Dravet syndrome in children.
Answer: CBD has no effect on embryonic development, thus preliminary studies suggest it is safe in pregnancy. Unlike THC, which has been shown in human studies to result in physical dependence (withdrawal & tolerance), human studies have revealed no physical dependence when using CBD.
Answer: Yes. CBD has a pharmacological profile very similar to atypical antipsychotic drugs. CBD also prevents the psychotic symptoms induced by high doses of THC.
If you want to read more from Dr Zachar, check out: ‘Ask A Doctor – THC VS. CBD – Addiction, Dependence and Abuse.‘
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Take two of the most hot-button, tendentious issues of our time – cannabis use and gun rights – combine them, and now we really have a debate. As the law currently stands, medical cannabis patients are not afforded their 2nd amendment right to bear arms. Technically, all cannabis consumers are banned from buying guns, but only medical […]
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Cannabis policy changes in Africa are welcome. But small producers are the losers by Clemence Rusenga
Cannabis is a drug crop with a long history in Africa. Alongside coca and opium poppy, it has been subjected to international control for nearly a century. The International Opium Convention of 1925 institutionalised the international control system and extended the scope of control to cannabis. In 1961 a new international convention was adopted to […]
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University of Sydney to Offer Free Cannabis Testing by Johnny Green
The University of Sydney is launching a fairly robust study in an attempt to, as the university describes it, “investigate cannabis consumption, behaviours, and attitudes among users.” Part of the study involves offering free, anonymous cannabis testing for people that cultivate their own cannabis in the Australian Capital Territory (ACT). Cannabis was decriminalized in 2020 in the […]
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